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Host-guest processes and formulations for delivering bio-affecting compounds

机译:用于传递生物影响化合物的宿主客体方法和配方

摘要

The invention relates to processes of making a composition having a host compound capable of accepting one or more bio-affecting guest compounds, and compositions formed by the processes. The processes comprise mixing, in any order: (i) a non-ionic surfactant selected from the group consisting of compounds having chemical structure where "-CH-O-CH-" represents an epoxide group, where Ra and Rb are hydrocarbons that can be the same or different, where at least one of the Ra and Rb hydrocarbons includes an epoxide group within 3 carbons of the hydrocarbon attachment to contribute to the desired hydrolipid balance of 7-9, where Rc is hydrogen or a methyl group, and where Rd is a methylene group, and ethyl group, or a structurally equivalent link with a bond length range about the same as or shorter than that provided by an ethyl group, and having a hydro-lipid balance in the range 7-9; (ii) an amphoteric surfactant selected from the group consisting of organic compounds having the chemical formula NH3-R-COOH, where R is a straight, branched, or aromatic hydrocarbon structure having 6-24 carbons; (iii) a solvent for the amphoteric surfactant; (iv) an aromatic selected from the group consisting of compounds having at (I) least one aromatic five or six-member ring; (v) an aluminum cation; (vi) a Lewis acid that is not a Bronsted-Lowry acid; and (vii) a Bronsted-Lowry acid.
机译:本发明涉及制备具有能够接受一种或多种生物影响客体化合物的主体化合物的组合物的方法,以及通过该方法形成的组合物。所述方法包括以任何顺序混合:(i)选自具有化学结构的化合物的非离子表面活性剂,其中“ -CH-O-CH-”代表环氧基,其中Ra和Rb是可以相同或不同,其中Ra和Rb烃中的至少一个在烃连接的3个碳原子内包含一个环氧基团,以促进所需的7-9的脂质平衡,其中Rc是氢或甲基,并且Rd是亚甲基和乙基,或者是键长范围与乙基所提供的键长大约相同或更短的结构上等效的键,并且其脂质平衡在7-9的范围内; (ii)两性表面活性剂,其选自具有化学式NH3-R-COOH的有机化合物,其中R是具有6-24个碳的直链,支链或芳族烃结构; (iii)两性表面活性剂的溶剂; (iv)一种芳族化合物,其选自具有(I)至少一个芳族五或六元环的化合物; (v)铝阳离子; (vi)不是布朗斯台德-洛里酸的路易斯酸; (vii)布朗斯台德-劳瑞酸。

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