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Delivering to eucaryotic cells bacterial proteins that are secreted via type iiisecretion systems
Delivering to eucaryotic cells bacterial proteins that are secreted via type iiisecretion systems
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机译:将通过iii型分泌系统分泌的细菌蛋白输送至真核细胞
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摘要
The present invention relates to a method for delivering effector proteins into a target cell. This method involves introducing into the target cell an effector protein fused to a protein transduction domain of a human immunodeficiency virus TAT protein or derivatives or functional analogs thereof. The present invention also relates to a fusion protein including an effector protein fused to a protein transduction domain of a human immunodeficiency virus TAT protein or derivatives or functional analogs thereof. Another aspect of the present invention relates to a DNA construct including a first DNA molecule encoding an effector protein and a second DNA molecule operatively associated with the first DNA molecule and encoding a protein transduction domain of a human immunodeficiency virus TAT protein or derivatives or functional analogs thereof and its use in a method for delivering effector proteins into a target cell.
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