GENE CONSTRUCT FOR PRODRUG ACTIVATION ENCODING A HETEROLOGOUS, GLYCOSYLPHOPHATI DYLINOSITOL-MODIFIED CARBOYPEPTIDASE G2 AND A CELL SURFACE TARGETTNG SIGNAL PEPTIDE

摘要

This invention relates particularly to gene directed enzyme prodrug therapy (GDEPT) using post translational glycosylphosphatildylinositol (GPI) addition to a prodrug activating enzyme to enable anchorage of the enzyme at the cell surface, particularly for use in cancer therapy. A preferred prodrug activating enzyme is carboxypeptidase G2.