SELECTIVE NUCLEAR RECEPTOR-TARGETED SYSTEMS FOR DELIVERY OF CYTOTOXINS TO CANCER CELLS FOR TARGETED PHOTODYNAMIC THERAPY

摘要

An estrogen/antiestrogen-porphyrin conjugate, their composition and methods for their use are claimed. The active compounds of the invention are conjugates consisting of an estrogen or anti estrogen portion, tether or linker portion and a porphyrin portion. The method of invention exploits an active process that involves strong and specific interactions between nuclear receptor and its cognate ligand.