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PROCESS FOR PREPARING 1,1'- 1,4-PHENYLENEBIS-(METHYLENE)-BIS-1,4,8,11-TETRAAZACYCLOTETRADECANE
PROCESS FOR PREPARING 1,1'- 1,4-PHENYLENEBIS-(METHYLENE)-BIS-1,4,8,11-TETRAAZACYCLOTETRADECANE
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机译:制备1,1'- 1,4,4-苯撑-(亚甲基)]-BIS-1,4,8,11-四氮杂环丁烷的方法
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摘要
An improved process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane comprising the selective functionalization of an acyclic tetraamine to obtain an acyclic ditosyl intermediate and an acyclic tritosyl intermediate in a first step, the independent dimerization/tosylation of the ditosyl intermediate and dimerization of the tritosyl intermediate to obtain a 1,4-phenylenebis-methylene bridged hexatosyl acyclic precursor in a second step, the cyclization of said precursor to obtain a hexatosyl cyclam dimer in a third step, and the detosylation of said cyclam dimer in a fourth step followed by basification to obtain the desired 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane.
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