HUMAN NUCLEIC ACID SEQUENCES FROM OVARIAN TUMOUR TISSUE

摘要

123 nucleic acid (cDNA) sequences (A), fully defined in the specification, that are highly expressed in ovarian tumor tissue (and some also in testis and breast cancer tissue), are new. Independent claims are also included for the following: (a) a subset (A') of 56 (A) that encode at least part of a gene product, the allelic variants of (A') and the complements of (A') or their allelic variants; (b) bacterial or phage artificial chromosomes and cosmid clones containing functional genes, or the chromosome region containing them, corresponding to (A') for use as gene transfer vehicles; (c) nucleic acid sequences containing part of (A) sufficiently long to hybridize with (A); (d) expression cassette (EC) comprising (A), or their fragments, plus control and regulatory sequences; (e) DNA fragments containing a gene isolated using (A); (f) host cells containing (A) as a heterologous component; (g) recombinant production of polypeptides (B), or their fragments, by culturing cells of (f); (h) antibody (Ab) directed against (B), or its fragments, encoded by (A); (j) 134 partial polypeptide sequences, fully defined in the specification, and sequences having at least 80% homology with them; (k) pharmaceutical composition containing at least one of these partial sequences; and (l) genomic genes, their promoters, enhancers, silencers, exon or intron structures, or splice variants obtained using (A).