ANTIGEN-BINDING PROTEINS COMPRISING A LINKER WHICH CONFERS RESTRICTED CONFORMATIONAL FLEXIBILITY

摘要

Use of a polypeptide linker group, the amino acid sequence of which group confers restricted conformational flexibility, as a linking group to link binding units, preferably antigen binding units comprising heavy chain variable domains derived from an immunoglobulin naturally devoid of light chains, in a multivalent binding protein.