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Single-chain antibodies recognizing the human vascular endothelial growth factor receptor-2 (VEGFR-2/KDR)
Single-chain antibodies recognizing the human vascular endothelial growth factor receptor-2 (VEGFR-2/KDR)
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机译:识别人血管内皮生长因子受体2(VEGFR-2 / KDR)的单链抗体
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摘要
The invention relates to specific single-chain antibodies (scFv's) recognizing the human vascular endothelial growth factor receptor-2 (VEGFR-2/KDR) which show no crossreactivity to the human VEGF-receptor 1 (VEGFR-1). The scFv's have clinical application as a marker for angiogenesis in cryosections of different human tissues and may be used as a tool for FACS analysis and cell sorting of vascular endothelial cells, progenitor cells and hematopoitic stem cells, which are positive for VEGFR-2 gene expression.
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