ANTISENSE OLIGONUCLEOTIDE FOR INHIBITING THE EXPRESSION OF THE ADHESION MOLECULE VERY LATE ANTIGEN 4 (VLA-4) IN HUMAN CELLS

摘要

The invention relates to a nucleic acid containing a nucleotide sequence which by binding to a transcription product of the gene coding for the alpha 4-chain of the adhesion molecule VLA-4 fully or at least partly inhibits expression of the adhesion molecule VLA-4 in mammal cells. The invention also relates to a vector containing said nucleic acid and to a pharmaceutical composition which contains the nucleic acid or vector and can be used, for example, for the mobilization of hemocytoblasts in mammals, for the treatment of malignant hematological diseases and for the treatment of pathological inflammatory responses in mammals.