57- 4-23- 57-Disubstituted 4-aminopyrido23-dpyrimidine compounds and their use as adenosine kinase inhibitors

摘要

The present invention requires the treatment of the compound of pharmaceutical compositions, a therapeutically effective amount, including in combination with acceptable carriers for the compounds of the method of inhibiting adenosine kinase by administering a compound of formula I, a therapeutically effective amount of a pharmaceutically It is in a mammal comprising administering to a mammal a method for treating cerebral ischemia, epilepsy, trauma perception, inflammation and sepsis, the method for producing the compound, and R ^1, R ^2, R ³ and R ⁴ to a to each defined as provides a compound of formula.; Formula I; Wherein; R ¹ and R ² are independently H, lower alkyl, C ₁ -C ₆ alkoxy C ₁ -C ₆ alkyl, aryl C ₁ -C ₆ alkyl, -C (O) C ₁ -C ₆ alkyl, -C each other ( O) aryl, -C (O) a 5 to 7 membered ring containing 1 or 2 additional heteroatoms selected from O, N or S bonded together with the nitrogen to which they are attached, selected from heterocyclic or optionally and forming;; R ³ is lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocyclic group, heteroarylalkyl or heterocycloalkyl (wherein heterocyclic aryl and heteroaryl groups are either directly or It is selected from the group consisting of indirect coupling is by) by a ring carbon;; R ⁴ is lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heterocyclic group heteroarylalkyl or is selected from the group consisting of heterocycloalkyl;; --- line represents a double bond that is optionally present is a suitable atom maintained.