- METHOD FOR PREPARING SALTS OF ASPARTAME FROM N-PROTECTED ASPARTAME

摘要

The present invention, by an acid treatment to eliminate the protective group N- protected aspartyl-phenylalanine methyl ester as from relates to a process for producing aspartyl phenylalanine methyl ester salt, N- protected aspartyl-phenylalanine methyl ester in the first step is in aqueous media, under methanol present, and from 0 to a temperature of 80 ℃ least aspartyl phenylalanine methyl ester and children seseol for a time that is completed the salt so conversion to the right of the sulfamic acid of 0.8 to 2 equivalents of O seseol farm acid and the reaction is , salts formed in the first step in the second step is characterized in that separation in precipitated form at a temperature below 30 ℃.