135- Trisubstituted 135-triazine derivatives for treatment of HIV infections

摘要

The present invention relates to the use of compounds of formula (I), their N-oxides, pharmaceutically acceptable salts and stereochemically isomeric forms for the manufacture of medicaments for the treatment of HIV (human immunodeficiency virus) infected patients.;In this formula,;A is CH, CR⁴Or N;;n is 0, 1, 2, 3 or 4;;R^OneAnd R²Each independently represent hydrogen, hydroxy, C_1-12Alkyl, C_1-12Alkyloxy, C_1-12Alkylcarbonyl, C_1-12Alkyloxycarbonyl, aryl, amino, mono-or di (C_1-12Alkyl) amino, mono-or di (C_1-12Alkyl) aminocarbonyl, wherein the above-mentioned C_1-12Each of the alkyl groups may be optionally and individually substituted;;R^OneAnd R²Together are pyrrolidinyl, piperidinyl, morpholinyl, azido or mono-or di (C_1-12Alkyl) amino C_1-4Alkylidene;;R³Is hydrogen, aryl, C_1-6Alkylcarbonyl, optionally substituted C RTI ID = 0.0 _1-6Alkyl,;Each R⁴Are independently selected from the group consisting of hydroxy, halo, C_1-6Alkyl, C_1-6Alkyloxy, cyano, aminocarbonyl, nitro, amino, trihalomethyl or trihalomethyloxy;;L is-X-R⁵Or-X-Alk-R⁶;Here, R⁵And R⁶Are each independently indanyl, indolyl or phenyl; Wherein each of said indanyl, indolyl or phenyl is substituted;;X is-NR³(= O)-or-S (= O)-,-NH-NH-,-N = N-,-O-,-S-,₂-;;Aryl is optionally substituted phenyl;;Het is an optionally substituted aliphatic or aromatic heterocyclic radical.;The present invention also relates to novel compounds which are subgroups of compounds of formula (I), processes for their preparation and pharmaceutical compositions containing them.