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Method for preparing novel fenofibrate galenic formulations galenic formulations obtained and applications
Method for preparing novel fenofibrate galenic formulations galenic formulations obtained and applications
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机译:非诺贝特新型盖仑制剂的制备方法及所得盖仑制剂的用途
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摘要
The present invention relates to a method for preparing a novel Galenic preparation which provides a phenobibrate having enhanced bioavailability upon oral administration, comprising the steps of (a) micronizing the phenobibrate; (b) granulating the undifferentiated phenobibrate in the presence of a surfactant, water and a water medium containing a water-miscible alcohol; And (c) drying the resulting granular material. The present invention also relates to a Galenic preparation obtained by the above method. These preparations are used for the preparation of medicaments for oral administration and comprise phenobibrate as an active substance and are particularly suitable for the treatment of hypercholesterolemia and hypertriglyceridemia.
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