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Improved bioavailability of itraconazole for oral administration
Improved bioavailability of itraconazole for oral administration
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机译:伊曲康唑口服的生物利用度提高
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摘要
The present invention, by shaping non-a, more particularly the determination of the itraconazole original formulation used for the antifungal agent at the same time as solid dispersion Sikkim the polyvinylpyrrolidone and the absorption enhancer said agent relates to itraconazole formulations for oral enhanced the bioavailability , polyvinylpyrrolidone is itraconazole the inclusion of money and the absorption enhancing agents to increase the solubility of the effective blood concentration of the body fluids in the digest gastrointestinal tract by taking a dose with less number of times of less drug than conventional sikimyeo significantly increase the bioavailability the depending reduce the burden on the usage and gastrointestinal discomfort due to excessive administration of drugs and, during storage relates to a formulation for itraconazole not amorphous itraconazole is not converted to a crystalline form of itraconazole that promote long-term storage stability dramatically orally.
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