NOVEL AZEPANES AND THEIR RING HOMOLOGUES FOR THERAPY AND PROPHYLAXIS OF PROTEIN KINASE MEDIATED DISEASES

摘要

The compounds of formula (I), and pharmaceutically acceptable acid addition salts thereof, are protein kinase inhibitors, which can be used in the treatment of diseases mediated by the enzyme, such as inflammatory diseases and the like:;Formula I;In this formula,;R^OneIs a phenyl or alpha-beta-naphthyl group which may be substituted by one or more substituents selected from the group consisting of hydroxy, lower alkyl, lower alkoxy, lower alkoxycarbonyl, phenoxy, acyloxy, hydroxyphenoxy-sulfonyl, halogen, N-lower alkyl-acylamino;;R²Is phenyl or phenyl substituted by hydroxy or acyloxy;;Y is a carbon-carbon bond or vinylene;;n is 1, 2 or 3;