BLOOD SUBSTITUTE AS OXYGEN TRANSPORTER, COMPOSITION FOR ITS PREPARING AND METHOD OF POLYMERIC MODIFIED HEMOGLOBIN PREPARING

摘要

FIELD: medicine, hematology. SUBSTANCE: invention relates to blood substitute as oxygen transporter that is an aqueous solution containing the following components, wt.%: polymeric modified hemoglobin, 0.9-1.1; sodium chloride, 1.0-1.2; glucose, 0.68-0.83; ascorbic acid, 0.023-0.027; and water up to 100. Invention relates to also the composition for preparing blood substitute as oxygen transporter containing, g per a single therapeutic dose (400 ml of solution): polymeric modified hemoglobin, 3.6-4.4; sodium chloride, 0.7-0.9; glucose, 2.7-3.3; ascorbic acid, 6^°C-0.11. Polymeric modified hemoglobin is prepared by interaction of deoxyhemoglobin with glutaric aldehyde modified at pH 6.4-6.6 and 4-6 C with substance of an order including dicarboxylic amino acid and sodium bisulfite. EFFECT: efficiency of proposed blood substitute is comparable with that of gaseous transport with human blood. 4 cl, 3 tbl, 2 ex