INSULIN DERIVATIVE, SOLUBLE PROLONGED PHARMACEUTICAL COMPOSITION, METHOD OF PROLONGATION OF HYPOGLYCAEMIC EFFECT IN TREATMENT OF DIABETIC PATIENTS

摘要

FIELD: medicine, endocrinology, pharmacy. SUBSTANCE: invention describes a novel derivative of insulin with amino acid sequence: SEQ ID NO : 2 where Xaa in positions A21 and B3 are any independent amino acid residues that can be encoded by genetic code with exception for Lys, Arg, Cys; Xaa in position B1 is Phe but this residue can be removed; Xaa in position B30 is (a) any amino acid residue that can be encoded by genetic code with exception for Lys, Arg, Cys and in this case -amino-group of Lys^B29 has lipophilic substituent or (b) this group is removed and -amino-group of Lys^B29 in this case has lipophilic substituent; and its any complexes with Zn²⁺ under condition that when Xaa in position B30 both are Thr, Ala and Xaa in position A21 and B3 both are Asn and Xaa in position B1 are Phe then insulin derivative is Zn²⁺-complex. Invention relates to also the soluble prolonged pharmaceutical composition based on thereof and method of prolongation of hypoglycaemic effect. Invention can be used for treatment of diabetic patients. EFFECT: new insulin derivative indicated above, valuable medicinal properties. 20 cl, 1 tbl, 3 dwg, 44 ex