NAPHTHYL-CONTAINING COMPOUNDS, PHARMACEUTICAL COMPOSITION, METHOD OF ATTENUATION OF POSTCLIMACTERIC SYNDROME SYMPTOMS AND OTHER ESTROGEN-ASSOCIATED PHYSIOLOGICAL STATES, METHODS OF SYNTHESIS OF NAPHTHYL-CONTAINING COMPOUNDS

摘要

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel naphthyl-containing compounds of the formula (I) where R¹ and R² mean H, -OH, -O-(C₁-C₄-alkyl), -OCO-C₆H₅, -OCO-(C₁-C₆-alkyl), -OSO₂-(C₄-C₆-alkyl); R³ means 1-piperidinyl, 1-pyrrolidinyl, methyl-1-pyrrolidinyl, dimethyl-1-pyrrolidinyl, 4-morpholino-, dimethylamino-, diethylamino-, 1-hexamethyleneimino-group and intermediate compounds that are useful for attenuation of symptoms of postclimacteric syndrome including osteoporosis, hyperlipidemia and estrogen-dependent cancer and inhibition of uterus fibroma, endometritis and proliferation of aorta smooth muscle cells. Also, invention describes methods of synthesis of these compounds. EFFECT: improved methods of synthesis, valuable medicinal properties. 46 cl, 4 tbl, 35 ex