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AGENT WITH LOW HEPATOTOXICITY FOR TREATMENT OF TUBERCULOSIS PATIENTS
AGENT WITH LOW HEPATOTOXICITY FOR TREATMENT OF TUBERCULOSIS PATIENTS
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机译：低肝毒性药物治疗结核病患者
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摘要
FIELD: organic chemistry, medicine, phthisiology, chemical-pharmaceutical industry. SUBSTANCE: invention proposes an agent that is a conjugate of isoniazide with dextran of molecular mass 65-75 kDa of the following formula: where R1 is H, glucose residue or polyglycosyl residue as given in a drawing; R2 is a residue of isoniazide of the formula: -NH-NH-; R3 is hydroxyl group. EFFECT: decreased hepatotoxicity of antituberculosis agent isoniazide, retained high-therapeutic effectiveness of isoniazide. 2 dwg
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机译：领域：有机化学，医学，药理学，化学制药工业。物质：本发明提出了一种试剂，其为异烟肼与分子量为65-75 kDa的葡聚糖的缀合物，其分子式为：<图像文件=“ 00000004.GIF” he =“ 39” id =“ imag00000004” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 116” />，其中R 1 是H，葡萄糖残基或聚糖基残基，如图中所示; R 2 是下式的异烟肼的残基：-NH-NH- <图像文件=“ 00000005.GIF” he =“ 16” id =“ imag00000005” imgContent =“未定义” imgFormat =“ GIF“ wi =” 22“ />; R 3 是羟基。效果：抗结核药异烟肼的肝毒性降低，保留了异烟肼的高疗效。 2 dwg
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