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Synthesis of indigo and 2,2'-bis(3-oxo-pyrrolo(2,3-b)pyridylidene) compounds, used for coloring keratinous fibers, e.g. human hair, involves enzymatic conversion and oxidation of tryptophan derivative with tryptophanase then oxidase
Synthesis of indigo and 2,2'-bis(3-oxo-pyrrolo(2,3-b)pyridylidene) compounds, used for coloring keratinous fibers, e.g. human hair, involves enzymatic conversion and oxidation of tryptophan derivative with tryptophanase then oxidase
Synthesis of indigo and 2,2'-bis(3-oxo-pyrrolo(2,3-b)pyridylidene) compounds (I) comprises (1) enzymatic conversion of a tryptophan derivative (II) with a tryptophanase enzyme in the presence of pyridoxal phosphate at 10-50 deg C and then (2) enzymatic oxidation to (I) in the presence of NADH (hydrated form of beta -nicotinamide-adenine dinucleotide acting as cofactor) and a suitable oxidase enzyme at 10-50 deg C. Synthesis of indigo and 2,2'-bis(3-oxo-pyrrolo(2,3-b)pyridylidene) compounds of formula (I) comprises: (1) enzymatic conversion of a tryptophan derivative of formula (II) with a tryptophanase enzyme in the presence of pyridoxal phosphate at 10-50 deg C; and then (2) enzymatic oxidation to (I) in the presence of NADH (hydrated form of beta -nicotinamide-adenine dinucleotide acting as cofactor) and a suitable oxidase enzyme at 10-50 deg C; X = nitrogen (N) or a methin group, CR4; R = hydrogen (H) or 1-4 carbon (C) alkyl; R1-4 = H, linear or branched 1-6 C alkyl, aryl, difluoromethyl, trifluoromethyl, halogen (fluorine (F), chlorine (Cl), bromine (Br) or iodine (I), amino, 1-6 C alkylamino, arylamino, hydroxyl, 1-4 C alkoxy, aryloxy, nitro, carboxy, carboxyalkyl, carboxamido, carboalkoxy, carboaryloxy or heterocyclyl; or R1R2 or R2R3 = methylenedioxy; R1-3 not = H in at least one case if X = CH. Independent claims are also included for multicomponent colorants for keratinous fibers.
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机译:靛蓝和2,2'-双(3-氧代-吡咯并(2,3-b)吡啶基)化合物的合成(I)包括(1)在存在下的情况下用色氨酸酶将色氨酸衍生物(II)酶促转化磷酸吡C醛在10-50℃下,然后(2)在NADH(β-烟酰胺-腺嘌呤二核苷酸作为辅因子的水合形式)和合适的氧化酶存在下,在10-50℃下酶氧化为(I)。式(I)的靛蓝和2,2'-双(3-氧代-吡咯并(2,3-b)吡啶基)化合物的合成包括:(1)用色氨酸酶将式(II)的色氨酸衍生物进行酶促转化。在10-50摄氏度下存在磷酸吡phosphate醛的酶;然后(2)在NADH(β-烟酰胺-腺嘌呤二核苷酸的水合形式作为辅因子)和合适的氧化酶存在下于10-50℃下酶氧化为(I); X =氮(N)或蛋氨酸基CR4; R =氢(H)或1-4个碳(C)烷基; R 1-4 = H,直链或支链的1-6 C烷基,芳基,二氟甲基,三氟甲基,卤素(氟(F),氯(Cl),溴(Br)或碘(I),氨基,1-6 C烷基氨基,芳基氨基,羟基,1-4 C烷氧基,芳氧基,硝基,羧基,羧基烷基,羧酰胺基,碳烷氧基,碳芳芳氧基或杂环基;或R 1 R 2或R 2 R 3 =亚甲二氧基;如果X = CH,则R 1-3在至少一种情况下不=H。还包括用于角蛋白纤维的多组分着色剂的独立权利要求。
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