Influence of TGF-beta by proteolytic enzymes

摘要

The present invention relates to the use of at least one proteolytic enzyme for influencing TGF-beta. Preferred proteolytic enzymes are trypsin, chymotrypsin, bromelain and papain. Rutoside can also be used. According to the invention, proteolytic enzymes and combination preparations of these enzymes with rutoside can be used for the treatment of various diseases and pathological conditions in which an elevated TGF-beta level is important, such as, for example, fibrosis, arteriosclerosis, burns, chronic infections, in particular rheumatoid arthritis, tumors , Rejection reactions against implants or grafts and diabetes-related diseases such as diabetogenic nephropathy and for the prevention of the side effects of bleomycin chemotherapy.