New human defensin hBD3, useful as antibacterial, antifungal and antitumor agent, particularly for control of multi-resistant pathogens

摘要

beta -Defensins (I). beta -Defensins of formula (I) are new Z1-CLHLQLLALKCCKI-Z2 (I). Z1 : optionally substituted amino group with at least one additional Cys; Z2 : peptide residue of up to 20 amino acids having at least two further adjacent Cys residues, or carboxy or a carboxy derivatives, with Z1 and Z2 same or different. An independent claim is also included for a pharmaceutical composition containing (I) as active ingredient. ACTIVITY : Antibiotic; antibacterial; antifungal; antitumor. Typically the preferred compound with Z1 = amino and Z2 = carboxy, has minimum inhibitory concentration 1-10 Microg/ml against various pathogens (no more details). MECHANISM OF ACTION : None given in the source material.