Sensor for an implanted therapeutic electro-stimulation apparatus has sensor elements with known molecules for the specific docking of organism molecules to monitor an increased range of parameters

摘要

The sensor, to register the condition of an organism to trigger a therapeutic apparatus, preferably for the electro-stimulation of the heart and the like, has at least one sensor element (2) to register molecular genetic information. The sensor, to register the condition of an organism to trigger a therapeutic apparatus, preferably for the electro-stimulation of the heart and the like, has at least one sensor element (2) to register molecular genetic information. The sensor element (2) has at least one docking element (4) where the molecules (6) of the organism can dock. The docking element (4) has a known specific docking characteristic, and contains a known molecule as a synthetic oligonucleotide and/or polymerase chain reaction (PCR) generated cDNA fragments (4). At least one sensor element (2) is at least doubled at the sensor (1), in an identical form. At least one measurement unit is linked to a majority of the sensor elements (2), which registers the hybridizing of a complementary molecule (6) of the organism at the known molecule (4). The measurement unit measures the electrical current which is generated by the hybridizing, a monitor to register the generated fluorescence, a monitor to detect the changes in the electrical charge distribution or a monitor to detect radioactive radiation generated by the hybridizing action. A memory stores the classification of the hybridizing for the known molecule (4), for comparison with known values stored in memory. The memory stores the timed development of the hybridizing action at the known molecule (4), to be compared with the measured timed development of the effect. The memory holds stored hybridizing patterns at the known molecule (4), for comparison with the measured hybridizing patterns. The sensor elements (2) are arranged in rows, with a number of identical rows assembled together in a chessboard pattern. The sensor elements are immobilized on a carrier substrate of glass, silvered glass, gallium arsenide, silicate and other materials. The sensor is fitted with at least 100 sensor elements (2) as docking elements (4), preferably at least 100 and especially preferred 10000. An independent claim is included for a medical therapeutic apparatus with a sensor (1) to deliver input signals, and a therapeutic applicator controlled by the output signals.