Magnetic nanoparticles carrying specific binding agent reactive with intracellular molecule, useful for separating cells, particularly cancerous, and biomolecules

摘要

Magnetic nanoparticles (A) with biochemical activity comprises a magnetic core particle (I) and an attached covering layer (C), and includes a group Z, i.e. nucleic acid, protein and/or peptide (or their derivatives), having at least one structure that binds specifically with a binding domain in an intracellular biomolecule. Magnetic nanoparticle (A) with biochemical activity comprises a magnetic core particle (I) and an attached covering layer (C). (A) comprise a compound of formula M-S-L-Z. Z = nucleic acid, protein and/or peptide (or their derivatives), having at least one structure that binds specifically with a binding domain in an intracellular biomolecule; M = magnetic core; S = biocompatible substrate; L = linker. Independent claims are also included for the following: (a) dispersion of (A) in a carrier liquid; (b) biochemically active compound of formula S-L-Z (II); (c) methods for preparing (A); and (d) method for preparing (II).