Spray-drying colloidal suspensions of polymer nanocapsules or nanospheres, e.g. containing drug such as diclofenac, including addition of silicon dioxide before drying to improve suspension stability

摘要

A method for spray-drying colloidal suspensions of polymer nanocapsules or nanospheres involves adding 0.5-5 wt. % silicon dioxide as drying adjuvant to a starting aqueous suspension of polymer-based particles of sub-micron diameter, followed by homogenization and spraying into a drying tower at feed rate 1.0-8.0 ml/minute, compressed air pressure 2000 kPa, air inlet temperature 110-190 deg C and air outlet temperature 110-190 deg C.