Process for the preparation of pharmaceutical compositions possessing neurogenic or non-neurogenic anti-inflammatory as well as analgetic effects

摘要

The invention relates to the use of peptide amides of formula (I) chemistry chemdraw filechemistry mol file;and phenylamino-oxoacetic acid derivatives of formula (II) chemistry chemdraw filechemistry mol file;as well as the salts of the above compounds as active substances for the preparation of pharmaceutical compositions possessing neurogenic and non-neurogenic antiinflammatory as well as analgetic effects. In the above formulae, the most important meanings of the substituents are as follows: ;X₁ means an aromatic D-amino acid group; ;X₂ stands for an aromatic amino acid group or a derivative thereof ring-substituted by hydroxyl group; ;X₃ means aromatic D-amino acid group; ;X₄ means threonyl or tryptophyl group; ;k is 0, 1, 2 or 3; ;n is 0, 3 or 4; ;R₁ stands for hydrogen or CH₃-CO- group, wherein A₂ is C_1-4 alkyl group; ;R₂ means hydrogen, phenyl or carbonyl group; ;R₃ represents hydrogen, amino or CF₃-CO-NH- group, ;R₄ stands for hydrogen, phenyl or amino group; or ;Q₁ means hydrogen, halogen, hydroxyl, nitro, amino, C_1-4 alkyl or alkoxy group; ;Q₂ stands for hydrogen, halogen, hydroxyl, or nitro group; ;Q₃ represents hydrogen, halogen, hydroxyl, nitro, CF₃, C_{1-4 alkyl or alkoxy group;} ;Q₄ and Q₅ each represents hydrogen, hydroxyl group, halogen, nitro group, -CF₃ group, C_1-4 alkyl or C_1-4 alkoxy group; or C_1-3 dialkylqmino group.