;wherein Ts is a tosylate group and R is an alkyl group, an unsubstituted phenyl or substituted phenyl ring, or a benzyl or substituted benzyl group; which comprises: ;(i) cyclising a compound of formula (II) chemistry chemdraw filechemistry mol file;in the presence of a suitable catalyst; and ;(ii) purifying and collecting the resultant compound of formula (I)."/>
Chemical synthesis of spirocyclic piperidines by double ring-closing metathesis
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Chemical synthesis of spirocyclic piperidines by double ring-closing metathesis
Chemical synthesis of spirocyclic piperidines by double ring-closing metathesis
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机译：双环易位化学合成螺环哌啶
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摘要
The present invention relates to a process for the preparation of a compound of formula (I) chemistry chemdraw filechemistry mol file;wherein Ts is a tosylate group and R is an alkyl group, an unsubstituted phenyl or substituted phenyl ring, or a benzyl or substituted benzyl group; which comprises: ;(i) cyclising a compound of formula (II) chemistry chemdraw filechemistry mol file;in the presence of a suitable catalyst; and ;(ii) purifying and collecting the resultant compound of formula (I).
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机译：本发明涉及一种制备式（I）化合物的方法 <图像文件=“ US20010029297A1-20011011-C00001.GIF” he =“ 76.80015” id =“ EMI-C00001” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 138.7449“ /> 化学化学绘图文件 化学mol文件 ;其中Ts为甲苯磺酸酯基，R为烷基，未取代的苯基或取代的苯环，或苄基或取代的苄基;其包括：;（i）环化式（II）的化合物 <图像文件=“ US20010029297A1-20011011-C00002.GIF” he =“ 80.65575” id =“ EMI-C00002” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 162.24705“ /> 化学化学绘图文件 化学mol文件 ;在合适的催化剂存在下; （ii）纯化并收集所得的式（I）化合物。
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