The Thyrotropin (TSH) receptor cleaving enzyme its recognition and domains within it contributing to receptor signalling

摘要

Thyrotropin receptor (TSHR) is enzymatically cleaved at residues 367-396 by the metalloprotease ADAM 10. A 16 amino acid peptide encompassing the ADAM 10 is identified, which blocks ADAM 10 cleavage of the receptor in an assay. Variants and mutants of such a peptide are claimed. Also identified is a ferritin binding region in TSHR. Alternatively claimed are nucleic acid probes that can be used in assays, such as on an array, to identify different metalloproteases of, for example the ADAM and ADAMTS families.