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Producing diastereomers of 4-hydroxyproline using 4-hp epimerase from Serratia marcescens or Acinetobacter baumanni
Producing diastereomers of 4-hydroxyproline using 4-hp epimerase from Serratia marcescens or Acinetobacter baumanni
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机译:使用粘质沙雷氏菌或鲍曼不动杆菌的4-hp Epimerase生产4-羟基脯氨酸的非对映异构体
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摘要
The present invention relates to two novel microorganisms, Acinetobacter baumanni WT-50/50-4A (ATCC 202144) and Serratia marcescens WT-L-4A1(RED) (ATCC 202145) characterized by 4-hydroxyproline epimerase activity. The compounds trans-4-hydroxy-L-proline (THLP) or cis-4-hydroxy-D-proline (CHDP) are converted with this epimerase activity to a mixture of THLP and CHDP. Additionally, the compounds trans-4-hydroxy-D-proline (THDP) or cis-4-hydroxy-L-proline (CHLP) are converted with this epimerase activity to a mixture of THDP and CHLP.
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