Derivatives of aminobenzoic and aminobiphenylcarboxylic acids useful as anti-cancer agents

摘要

The present invention provides compounds having the formula: ;wherein n is 0 or 1; ;R is —NH₂ or ;wherein R¹ and R² are independently selected from the group consisting of H, alkyl, aralkyl, heteroaralkyl, carboxy, carboxyalkyl, and carbamoyl;;Q is R³C(O)— or ;wherein R⁵ is selected from the;group consisting of H, alkyl, aralkyl, heteroaralkyl, and carbamoylalkyl, and R³ and R⁴ are selected from the group consisting of H, alkyl, alkoxy, arylalkoxy, aralkyl, heteroaralkyl, and carbamoylalkyl;;the Q—NH—(CH₂)_n— and the —C(O)R substituents of the compound of formula I are independently positioned ortho, meta, orpara relative to the carbon atoms that form the bond between the two phenyl groups to which said substituents are bound, with the proviso that said substituents are not both positioned ortho; and;the Q—NH—(CH₂)_n and the —C(O)R substituents of the compound of formula II are positioned meta orpara to each other;;or a biolabile ester thereof, or a pharmaceutically acceptable salt thereof. The compounds are useful for treating uPA- or uPAR-mediated disorders, e.g., tumor metastasis, tumor angiogenesis, restenosis, chronic inflammation, or corneal angiogenesis.