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Isolation of naturally occuring isoflavanone and some clinical uses thereof
Isolation of naturally occuring isoflavanone and some clinical uses thereof
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机译：天然异黄酮的分离及其临床应用
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摘要
A compound of general formula I ;in which the 2-3 bond in ring C could be double or single bond. Ring B and its substituents may be attached at position 2 (at J) in ring C. The key feature in the modifications is that the prenylation must not cyclize through the free OH groups(s) at ortho position to the prenylation. Atoms attached at X in ring C may be S or N or P or C or O or pharmaceutically acceptable metal or CH2. Atoms attached to Y could be S or N or P or O or alkyl (C1-C8) or alkoxy (C1-C8) or alkylthio (C1-C8) or aryloxy (C6-C10) or alkoxycarbonyl (C2-C8) or heterocycloalkoxy (C2-C10) pharmaceutically acceptable metal or CH2 or the like; the prenylation could be attached at any position L or V or G or F or M or W or U or Z or Q; the prenylation could be singly or multiple or in combination; the prenylation could be penteny group (—CH2—CH═C(CH3)2) or geranyl (—CH2CH═C(Me)CH2CH2CH═C(Me(2) or lavandulyl (—CH2—CH(C(CH3)═CH2)CH2CH═C(CH3)2} or -o- pentenyl (o-CH2—CH═C(CH3)2) or -o- geranyl (o-CH2CH═C(Me)CH2CH2═CH(Me)2) or o-lavandulyl {-o-CH2—CH(C(CH3)═CH2)CH2CH═C(CH3)2} or substituted pentenyl, geranyl and lavandulyl with hydroxy, alkoxy (C1-C8), alkylthio (C1-C8), aryloxy (C6-C10), alkoxycarbonyl (C2-C8) or heterocycloalkoxy (C2-C10) or halogen; on the ortho positions of the above groups could be substituted with veratryl or anisyl or epoxyangelyl or isobutanolyl or angelyl or 6-dimethylpyrane or formylloxy or isoamyl or 3-methylbutyl or -o-heterocycle (C2-C10) or alkoxy (C1-C8) or alkylthio (C1-C8) or aryloxy (C6-C10) or alkoxycarbonyl(C2-C8) or heterocycloalkoxy (C2-C10) or amino (NH2) or glycosides (1-10 sugar units) or o-glycosides (1-10 units) or oxyacetic acids or Schiff base or dialkylaminoalkyl (C1-C10) or amino acid esters or flavan or substituted aryl groups with alkyl (C1-C10) or phenoxy or alkenyl (C3-C8) or phenyl substituted with one to three groups, these being hydroxy, halogen, alkynyl (C2-C8) or nitro or cyano or acetates, any position L or V or G or F or M or W or U or Z or Q which are not substituted with the prenylation as above may be substituted such as to prevent internal cyclization of the of the prenylation, groups which can be attached to L or V or G or F or M or W or U or Z or Q could be alkoxy (C1-C8) alkylthio (C1-C8), aryloxy (C6-C10), alkoxycarbonyl (C2-C8) or heterocycloalkoxy (C2-C10) or halogen or veratryl or anisyl or epoxyangelyl or isobutanolyl or angelyl or 6-dimethylpyrane or formylloxy or isoamyl or 3-methylbutyl or o-heterocycle (C2-C10) or alkoxy (C1-C8) or alkylthio (C1-C8) or aryloxy (C6-C10) or alkoxycarbonyl(C2-C8) or heterocycloalkoxy (C2-C10) or amino (NH2) or glycosides (1-10 sugar units) or o-glycosides (1-10 units) or oxyacetic acids or Schiff base or dialkylaminoalkyl (C1-C10) or amino acid esters (C1-C10) or extended amines (C1-C10, N1-N6) or sulphate esters or flavan or substituted flavan or substituted aryl groups with alkyl(C1-C10) or phenoxy or alkenyl (C3-C8) or phenyl substituted with one to three groups; these being hydroxy (except ortho to prenylation), halogen, or alkynl (C2-C8) or nitro or cyano or acetates or saturated or unsaturated aliphatic (C2-C8), cycloaliphatic (C1-C15) or aromatic hydrocarbonyl (C1-C15) or bridged cycloalkyl (C1-C10) or cycloakenyl (C1-C10) or furanylalkyl (C1-C15) alkylthioalkyl (C5-C15) or alkylene (C4-C10) or indolyl or pyridinyl or pyrrolinyl or quinolinyl or thienyl or tert-butoxycarbonyl amino or hydrogen or hydroxy protecting groups or functional groups which increase water solubility of the analog or amino protecting group or sulfhydryl protecting group or carbamat (C2-C6) or heteroaryl or crotyl.
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