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Methods of screening competitors of OB-R binding to SHP-2-SH2 peptides
Methods of screening competitors of OB-R binding to SHP-2-SH2 peptides
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机译:筛选与SHP-2-SH2肽结合的OB-R竞争者的方法
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摘要
The present invention relates to methods for identifying therapeutic agents that enhance the effect of leptin, an adipocyte-derived cytokine that regulates food intake and body weight. The invention further provides for use of agents identified using this assay system to enhance the interaction between leptin and its receptor, OB-R, thereby boosting leptin's weight-reducing effects in obese individuals.
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