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Methods for the detection of a novel hepatitis C virus (HCV) terminal 3 noncoding region
Methods for the detection of a novel hepatitis C virus (HCV) terminal 3 noncoding region
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机译:检测新型丙型肝炎病毒(HCV)末端3非编码区的方法
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摘要
The invention relates to the discovery of a novel RNA sequence at the 3 terminal sequence of hepatitis C virus (HCV) genome RNA. Included in the invention are the 3 sequence, its complement, and their use for nucleic-acid based diagnostics and for developing and evaluating novel anti-HCV therapies. This sequence element, which is conserved among HCV genotypes, is likely to be essential for viral replication, and required for construction of full-length HCV cDNA clones capable of yielding infectious RNA, progeny virus or replication-competent HCV replicons. Such functional clones are useful tools for evaluation of therapeutic approaches and as substrates for developing candidate attenuated or inactivated HCV derivatives for vaccination against HCV.
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