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Sustained release pharmaceutical matrix tablet of pharmaceutically acceptable salts of diclofenac and process for preparation thereof
Sustained release pharmaceutical matrix tablet of pharmaceutically acceptable salts of diclofenac and process for preparation thereof
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机译:双氯芬酸药学上可接受的盐的缓释药物基质片剂及其制备方法
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摘要
The present invention provides a novel sustained release composition and method for making such a composition of diclofenac and its pharmaceutically acceptable salts. The composition of the present invention provides a sustained release formulation of diclofenac and pharmaceutically acceptable salts thereof which is suitable for once daily administration and provides controlled and long lasting in vivo release. The composition comprises: (a) about 5-25% by weight of hydroxyethyl cellulose; (b) about 5-75% by weight of lactose; (c) about 0-3% by weight of silicone dioxide; (d) about 0.5-5% by weight of PVP; (e) about 3% by weight of talc; and f) about 3% by weight of magnesium stearate.
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