H ▲ ++ ▼ -Quinoline derivatives as ATPase inhibitors and bone resorption inhibitors

摘要

This invention relates to a compound of formula (I) wherein: R1 is lower alkyl, aryl, a heterocyclic group, etc., R2 is hydrogen, lower alkyl, etc., R3 is hydrogen or lower alkyl, R4 is hydrogen, halogen, lower alkyl, etc., R5 and R6 are each hydrogen, etc., R7 is a heterocyclic group or aryl, each of which may be substituted with substituent(s), X is O or S, and Y is -NHCO-, etc., and pharmaceutically acceptable salt thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prevention and/or the treatment of bone diseases caused by abnormal bone metabolism in human being or animals.