Polymorphisms in the human beta1 integrin subunit gene suitable for diagnosis and treatment of integrin ligand-mediated diseases

摘要

This invention relates to polymorphisms in the human beta 1 integrin subunit gene, in particular at positions 590, 751, 1206 and 1282 in the promoter as defined by EMBL ACCESSION NO. X68969, positions 562, 886, 1189, 1279 and 1942, in the coding region as defined by EMBL ACCESSION NO. X07979, and position 2502 in the 3'-untranslated region as defined by EMBL ACCESSION NO. X07979. The invention also relates to methods and materials for analysing allelic variation in the beta 1 integrin subunit gene, and to the use of beta 1 integrin subunit polymorphism in the diagnosis and treatment of integrin ligand mediated diseases such as multiple sclerosis, rheumatoid arthritis, atherosclerosis and allergic asthma.