Fibrin tissue adhesive preparation and method for producing the same

摘要

A solid formulation of a fibrin tissue adhesive for use in medical procedures is disclosed. The formulation is a mixture containing thrombin and fibrinogen with factor XIII in a pourable solid granule form. The granules are obtained by drying the protein solutions or suspensions in a fluidized bed apparatus. Preferably, the granules have a particle size between 20 and 1,000 um.