Isolation and elucidation of the structure of a compound that inhibits the growth of human cancer cells named Agelagrastatin.

摘要

A human cancer cell line bioassay-directed investigation of the Western Pacific marine sponge agelas sp. led to isolation of a trace (7.42x10-6% yield) cancer cell growth inhibitor (lung NCI-H460 GI50 0.77 mug/ml to ovary OVCAR-3 GI50 2.8 mug/ml) designated agelagalastatin. Agelagalastatin is the first example of a natural product containing a digalactofuranosyl unit.