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Anticancer drug aldehyde conjugate drug with enhanced cytotoxicity: compounds, compositions and methods
Anticancer drug aldehyde conjugate drug with enhanced cytotoxicity: compounds, compositions and methods
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机译:具有增强的细胞毒性的抗癌药物醛结合药物:化合物,组合物和方法
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摘要
Monomeric and dimeric anti-cancer drug aldehyde conjugate compounds and pharmaceutically acceptable salts thereof. Specifically, monomeric and dimeric aldehyde conjugates of 1-2, dihetero-substituted anti-cancer drugs, including monomeric and dimeric aldehyde conjugates of anthracyclines, are provided. Also provided are pro-drugs which, after administration, release monomeric aldehyde conjugates. Further provided are pharmaceutical and therapeutic compositions containing anti-cancer drug aldehyde conjugates and methods of treating cancer using the aldehyde conjugates.
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