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Glass make primary packing material for freezing dry matter, defective generation obstruction modulo of freezing dry matter and manufacturing method null of freezing
Glass make primary packing material for freezing dry matter, defective generation obstruction modulo of freezing dry matter and manufacturing method null of freezing
PURPOSE: To improve the adherence, the closeness and the shape of a dried product, and prevent the undesirable distribution of the dried product to the shoulder part, the spearlike part of a receptacle or the surface of a vial that comes in contact with a stopper, by coating the inner surface of glass with silicon. ;CONSTITUTION: Glass whose surface is coated with silicon is used of the production of the lyophilized product(LP) and as a primary wrapping material for the LP. Silicon plating can be applied for a syringe to reduce the internal friction between a piston or a stopper (in the case of a double syringe) and the outer tube of the syringe. For example, in the case of an active ingredient consisting of substances such as peptide and protein and having a possibility of adhering to glass, silicon plating reduces the adherence to it. Or, the product to be lyophilized is put into the primary wrapping material made of glass each inner surface of which is coated with a silicon layer, and is lyophilized under the formation of leaving no space between products in the receptacle.;COPYRIGHT: (C)1993,JPO
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