Thrombin preparation and thrombin product and fibrin sealant method using the same

摘要

The invention employs liposomes having an outer surface presenting both acidic and basic polar groups, for example phosphatidyl for rapid, high yield generation of thrombin from prothrombin-containing material. The source material for the prothrombin can be the subject to be treated with the product thrombin, providing an autologous thrombin product. Also, a fibrinogen component can be generated from the same blood sample, yielding a fully autologous fibrin sealant when activated with thrombin product from the same blood sample.