Production manner null of kinoronkarubon

摘要

PURPOSE: To industrially and advantageously produce a quinolonecarboxylic acid derivative useful as an antimicrobial agent by using a new specific quinolonecarboxylic acid derivative as a raw material or an intermediate. ;CONSTITUTION: The objective 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3- methylaminopiperidino)-4-oxo-3-quinolinecarboxylic acid, expressed by formula II and useful as an antimicrobial agent is obtained simply by hydrolyzing a new compound expressed by formula I (R₁ and R₂ are H or alkyl; R₁ and R₂, together with N, form a 5- or 6-membered cyclic amine). This new compound expressed by formula I is obtained by reacting a new compound expressed by formula III (X₁ and X₂ are halogen) with 3-methylaminopiperidine or its hydrochloride and further reacting the resultant new compound expressed by formula IV with a compound expressed by formula V (X₃ is alkali metal).;COPYRIGHT: (C)1994,JPO&Japio