PROBLEM TO BE SOLVED: To provide a method for synthesizing 2,3-di-substituted piperidines in high stereoselectivity and simply synthesizing febrifugine and its derivative. SOLUTION: A ketone represented by the following chemical formula (1) is reacted with tin (II) triflate and diisopropylethylamine and the reaction product is reacted with 2,3-di-substituted-N-benzyloxycarbonylpiperidine represented by the following chemical formula (2) (R1 and R2 are each a hydrocarbon group which may have same or different substituent group; Cbz is benzyloxycarbonyl group) in the presence of Lewis acid and the reaction product is treated with a strong acid to produce the objective febrifugine represented by the following chemical formula (3).
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