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INHIBITOR OF INTERACTION BETWEEN mot-2 PROTEIN AND p53 PROTEIN COMPRISING CATIONIC RHODACYANINE-BASED DYE DERIVATIVE AS ACTIVE INGREDIENT
INHIBITOR OF INTERACTION BETWEEN mot-2 PROTEIN AND p53 PROTEIN COMPRISING CATIONIC RHODACYANINE-BASED DYE DERIVATIVE AS ACTIVE INGREDIENT
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机译:含有阳离子类花红素的染料衍生物作为活性成分的mot-2蛋白和p53蛋白相互作用的抑制剂
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摘要
PROBLEM TO BE SOLVED: To provide a new drug use of 1-ethyl-2-{[3-ethyl-5-(3- methylbenzothiazolin-2-ylidene)]-4-oxothiazolidin-2-ylidenemethyl}pyridinium chloride and its derivative by elucidating a target molecule of the compounds in a cell and the mechanism of actions of the compounds in the cell.;SOLUTION: It has been fount out that the 1-ethyl-2-{[3-ethyl-5-(3- methylbenzothiazolin-2-ylidene)]-4-oxothiazolidin-2-ylidenemethyl}pyridinium chloride and its derivative bind to mot-2 which is a member of heat shock proteins 10 (hsp70) in the cell and inhibit the interaction between the mot-2 and a cancer inhibiting protein p53 that is a target thereof.;COPYRIGHT: (C)2001,JPO
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