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Synthetic peptides that enhance atherogenic lipoprotein uptake and lower plasma cholesterol
Synthetic peptides that enhance atherogenic lipoprotein uptake and lower plasma cholesterol
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机译:增强动脉粥样硬化脂蛋白摄取并降低血浆胆固醇的合成肽
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摘要
The present invention provides novel synthetic apolipoprotein E (ApoE)-mimicking peptides wherein the receptor binding domain of apolipoprotein E is covalently linked to 18A, the well characterized lipid-associating model class A amphipathic helical peptide. Such peptides enhance low density lipoprotein (LDL) and very low density lipoprotein (VLDL) binding to and degradation by fibroblast or HepG2 cells. Also provided are possible applications of the synthetic peptides in lowering human plasma LDL/VLDL cholesterol levels, thus inhibiting atherosclerosis.
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