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Methods for the high-resolution identification of solvent-accessible amide hydrogens in protein binding sites
Methods for the high-resolution identification of solvent-accessible amide hydrogens in protein binding sites
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机译:高分辨率识别蛋白质结合位点中溶剂可及的酰胺氢的方法
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摘要
The present invention provides methods whereby the positions of peptide amide groups that are labeled with a heavy hydrogen in a polypeptide or protein can be localized at high resolution. The methods are useful for determining which peptide amide groups in a polypeptide or protein are accessible to solvent, mapping the binding site and/or binding surface of a binding protein, and/or studying allosteric or other conformational changes in a polypeptide or protein which alter the rates at which certain peptide amide hydrogens exchange with solvent.
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