Adsorption of polyampholytes to charged surfaces and assays incorporating same

摘要

Polyampholytes including fibronectin and aggrecan are made to aggregate and form fibrillar lattice networks environment free of cells, extraneous proteins and other materials which may be present in an extracellular matrix. A composition having sufficient charge density is utilized to cause aggregation and self-assembly of such polyampholytes and to provide an assay for determining the effects of environmental agents on such aggregation and self-assembly.