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P53-specific T cell receptor for adoptive immunotherapy
P53-specific T cell receptor for adoptive immunotherapy
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机译:P53特异性T细胞受体用于过继免疫治疗
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摘要
The present invention relates to molecular cloning of cDNA for both A and B chains of hu p53-specific, HLA restricted mu TCR, transfer of the cDNA to hu T cells, and functional expression of the p53-specific TCR in hu CTLs. The functional expression of the mu TCR results in the recognition of endogenously processed hu p53 expressed in tumor cells. The invention thus also relates to an anti-cancer immunotherapy by the adoptive transfer of TCR gene modified autologous T cells.
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机译:本发明涉及hu p53特异性,HLA限制的mu TCR的A链和B链的cDNA的分子克隆,该cDNA向hu T细胞的转移以及在hu CTL中p53特异性TCR的功能性表达。 mu TCR的功能性表达导致识别在肿瘤细胞中表达的内源性加工过的hu p53。因此,本发明还涉及通过TCR基因修饰的自体T细胞的过继转移的抗癌免疫疗法。
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