Pipecolinic acid derivatives, method of manufacturing the same and therapeutic agents containing these compounds

摘要

The present invention provides a compound of the general formula (I) or a pharmaceutical salt thereof, chemistry chemdraw filechemistry mol file;wherein, when R₁ and R₂ are the same they are represented by O, N, OR₉ (where R₉ is hydrogen, lower alkyl or benzyl), when R₁ and R₂ are different and one of R₁ and R₂ is represented by hydrogen, the other is represented by R₅R₆, (where R₅ is O, NH, NHCO, or NHSO₂, and where R₆ is hydrogen, lower alkyl, PhR₇, (CH₂)nOPhR₇, (where n1-6, R₇ is hydrogen, hydroxy, lower alkyl, lower alkoxy, halogen, nitro, or pyridyloxy), indolyl, N-oxidepyridyl, phthalimide, thienyl, or pyridyl); R₃ represents COOH, COOEt, COOMe, CH₂N(OH)CHO, or CONHOH; R₄ represents lower alkyl, thienyl, PhR₈ (where R₉ represents hydroxy, lower alkyl, lower alkoxy, nitro, halogen, pyridyloxy, or phenyl group substituted hydrogen, lower alkyl, lower alkoxy, hydroxy, and halogen), and methods of making compounds within the class of the general formula (I).