Novel polypeptides within the tumor necrosis factor receptor superfamily and uses therefor

摘要

The present invention relates to the discovery and characterization of two novel polypeptides within the tumor necrosis factor (TNF) receptor superfamily. The first receptor of the invention, Tango-63d, encodes a 440 amino acid polypeptide and the second receptor of the invention, Tango-63e, encodes a 411 amino acid polypeptide. ;The invention encompasses nucleic acid molecules encoding Tango-63d and Tango-63e or mutant forms thereof which encode dysfunctional receptor polypeptides, vectors containing these nucleic acid molecules, cells harboring recombinant DNA molecules encoding Tango-63d and/or Tango-63e or mutant forms thereof, host fusion proteins which include functional or dysfunctional Tango-63d or Tango-63e, transgenic animals which express Tango-63d and/or Tango-63e, screening methods and therapeutic methods employing the nucleic acid molecules and polypeptides described above, substantially purified Tango-63d, substantially purified Tango-63e and therapeutic compositions containing these nucleic acid molecules and polypeptides.